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标题：Relaxant Effect of Xanthomicrol and 3α-Angeloyloxy-2α-hydroxy-13,14Z-dehydrocativic Acid from Brickellia paniculata on Rat Uterus
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作者：Hector Ponce-Monter ; Salud Perez ; Miguel Angel Zavala 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2006
卷号：29
期号：7
页码：1501-1503
DOI：10.1248/bpb.29.1501
出版社：The Pharmaceutical Society of Japan
摘要：Brickellia paniculata has been used as spasmolytic in Mexican traditional medicine. Xanthomicrol and 3α-angeloyloxy-2α-hydroxy-13,14 Z -dehydrocativic acid (AAHDD) are two of the main leaf components with antispasmodic activity. However, their mechanism of action remains unknown. An in vitro comparative study between xanthomicrol and AAHDD on rat uterus precontracted by either KCl (60 m M ) or oxytocin (10 mIU/ml) was carried out to investigate the mechanism of action of these compounds on smooth muscle. Relaxant effect was measured as median inhibitory concentration (IC₅₀) and maximal effect as maximal relaxant response ( R _max). Xanthomicrol was significantly more potent than AAHDD in inhibiting contractions induced by KCl 60 m M , whereas AAHDD was more potent than xanthomicrol in inhibiting contractions induced by oxytocin 10 mIU/ml. These results suggest that xanthomicrol induces a greater blocking effect on voltage-operated calcium channels than on receptor-operated gates.
关键词：Brickellia paniculata;antispasmodic effect;rat uterus