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标题：In Vivo Characterization of Sedative Activities of Fossilia Mastodi OSSIS
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作者：Jeoung-Hee Ha ; Maan-Gee Lee ; Soo-Min Chang 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2006
卷号：29
期号：7
页码：1414-1417
DOI：10.1248/bpb.29.1414
出版社：The Pharmaceutical Society of Japan
摘要：Fossilia Mastodi O SSIS , which is a skeletal fossil of a Mastodon, an ancient mammal, has been found to have anxiolytic, sedative and anticonvulsant activities in Oriental medicine. In this study, in vivo characterization of the sedative activities of Fossilia Mastodi O SSIS was performed in order to obtain basic information for the development of a putative natural sedative. The 80% methanol extract of Fossilia Mastodi O SSIS given per os at a dose of 3 g/kg in mice showed anxiolysis, potentiation of pentobarbital sleeping time, reduced locomotor activity, and anticonvulsive activity. Fossilia elicited GABA_A receptor-mediated anxiolysis. The data obtained suggest that the 80% methanol extract of Fossilia Mastodi O SSIS contains some biologically active principles with sedative activity.
关键词：Fossilia Mastodi;natural sedative;γ-aminobutyric acid (GABAA) receptor;fossil