文章基本信息

标题：A Norbergenin Derivative Inhibits Neuronal Cell Damage Induced by Tunicamycin
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作者：Shinya Suzuki ; Yui Okuse ; Masafumi Kawase 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2006
卷号：29
期号：7
页码：1335-1338
DOI：10.1248/bpb.29.1335
出版社：The Pharmaceutical Society of Japan
摘要：Several chemically synthesized compounds were examined for protective effects against the cell damage in tunicamycin-treated human neuroblastoma IMR-32 cells. Among the compounds tested, an antioxidant, Norbergenin-11-caproate (10 μ M ), exhibited complete protection against the cell growth inhibitory effect of tunicamycin but did not inhibit the induction of Bip/GRP78 mRNA by tunicamycin. Both norbergenin-11-caproate and α-tocopherol completely inhibited the production of reactive oxygen species induced by tunicamycin, however, α-tocopherol inhibited tunicamycin-induced cell damage only partially, even at 100 μ M . These findings suggest the potential of Norbergenin-11-caproate for therapeutic application in endoplasmic reticulum (ER) stress-dependent diseases implicating a specific mechanism other than anti-oxidative one.
关键词：tunicamycin;norbergenin;endoplasmic reticulum (ER) stress;antioxidant;neuroblastoma