文章基本信息

标题：Perifollicular Fibrosis: Pathogenetic Role in Androgenetic Alopecia
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作者：Hyeon Gyeong Yoo ; Jin Sook Kim ; Se Rah Lee 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2006
卷号：29
期号：6
页码：1246-1250
DOI：10.1248/bpb.29.1246
出版社：The Pharmaceutical Society of Japan
摘要：Androgenetic alopecia (AGA) is a dihydrotestosterone (DHT)-mediated process, characterized by continuous miniaturization of androgen reactive hair follicles and accompanied by perifollicular fibrosis of follicular units in histological examination. Testosterone (T: 10⁻⁹—10⁻⁷ M ) treatment increased the expression of type I procollagen at mRNA and protein level. Pretreatment of finasteride (10⁻⁸ M ) inhibited the T-induced type I procollagen expression at mRNA (40.2%) and protein levels (24.9%). T treatment increased the expression of transforming growth factor-beta 1 (TGF-β1) at protein levels by 81.9% in the human scalp dermal fibroblasts (DFs). Pretreatment of finasteride decreased the expression of TGF-β1 protein induced by an average of T (30.4%). The type I procollagen expression after pretreatment of neutralizing TGF-β1 antibody (10 μg/ml) was inhibited by an average of 54.3%. Our findings suggest that T-induced TGF-β1 and type I procollagen expression may contribute to the development of perifollicular fibrosis in the AGA, and the inhibitory effects on T-induced procollagen and TGF-β1 expression may explain another possible mechanism how finasteride works in AGA.
关键词：fibrosis;finasteride;androgenetic alopecia;type I procollagen;TGF-β1