文章基本信息

标题：Alleviation of Picryl Chloride-Induced Delayed Type Hypersensitivity Reaction by Saponin Fraction of Gleditsia sinensis
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作者：Li-Fei Hou ; Yue Dai ; Yu-Feng Xia 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2006
卷号：29
期号：5
页码：1056-1059
DOI：10.1248/bpb.29.1056
出版社：The Pharmaceutical Society of Japan
摘要：The objective of the present study was to investigate the effects of saponin fraction from anomalous fruits of Gleditsia sinensis (SFGS) on picryl chloride-induced delayed type hypersensitivity (PC-DTH) and functions of T lymphocytes and macrophages in mice. SFGS (100, 200 mg/kg), orally administered during either sensitization stage or effector stage, produced remarkable inhibition of PC-DTH. In vitro , SFGS (1, 2, 4 μg/ml) concentration-dependently attenuated concanavalin A (Con A)-elicited mouse splenocyte proliferation and interleukin 2 (IL-2) production. At concentrations of 10 and 20 μg/ml, SFGS inhibited lipopolysaccharide (LPS)-induced production of nitric oxide and interleukin 1β (IL-1β) of mouse peritoneal macrophages. The findings indicate that SFGS attenuates PC-DTH in mice, which is probably mediated by preventing proliferation and differentiation of T cells during the sensitization stage and suppressing activation of macrophages during the effector stage.
关键词：Gleditsia sinensis;delayed type hypersensitivity;T lymphocyte;macrophage