文章基本信息

标题：The Cytotoxic Saponin from Heat-Processed Achyranthes fauriei Roots
本地全文：下载
作者：Hye Hyun Yoo ; Sung Won Kwon ; Jeong Hill Park 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2006
卷号：29
期号：5
页码：1053-1055
DOI：10.1248/bpb.29.1053
出版社：The Pharmaceutical Society of Japan
摘要：An extract of heat-processed Achyranthes fauriei roots showed more potent cytotoxic activity against human hepatoma SK-Hep-1 cells than that of the crude plant. Employing a bioassay-linked HPLC-ELSD (high performance liquid chromatography-evaporative light scattering detector) method, followed by silica gel column chromatography, a cytotoxic triterpenoid saponin, chikusetsusaponin IVa was isolated. It is contributive to the increased cytotoxic activity of the heat-processed. The amount of chikusetsusaponin IVa from the roots of Achyranthes fauriei was significantly increased after heat-processing.
关键词：Achyranthes fauriei;Amaranthaceae;cytotoxic activity;bioassay-linked HPLC-ELSD;chikusetsusaponin IVa