文章基本信息

标题：Inhibition of Putrescine Aminopropyltransferase Influences Rat Liver Regeneration
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作者：Masaki Kobayashi ; Koichi Takao ; Yasuo Shiota 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2006
卷号：29
期号：5
页码：863-867
DOI：10.1248/bpb.29.863
出版社：The Pharmaceutical Society of Japan
摘要：A close relationship between rat liver regeneration and the concentration ratio of spermidine to spermine (spd : spm) was demonstrated by the oral administration of trans -4-methylcyclohexylamine (MCHA), a specific inhibitor of putrescine aminopropyltransferase. A decrease in recovery rate of remnant liver with MCHA, as a percentage index of remnant liver weight to body weight, correlated well with a decrease of the spd : spm value, with a correlation coefficient of 0.952 for the remnant livers on day 3 after partial hepatectomy. The decrease in recovery rate could be explained by a prolonged cell cycle based on the data of the proliferating cell nuclear antigen labelling index and mitotic cell index in both livers of day 2 and day 3 after partial hepatectomy. The results presented here will give a new aspect in the field of polyamine regulation to control cell growth in vivo .
关键词：spermidine synthase;trans-4-methylcyclohexylamine;rat liver regeneration;proliferating cell nuclear antigen;growth inhibition