文章基本信息

标题：Pharmacokinetic Study of Ketoprofen Isopropyl Ester-Loaded Lipid Microspheres in Rat Blood Using Microdialysis
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作者：Haibing He ; Xing Tang ; Fude Cui 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2006
卷号：29
期号：4
页码：841-845
DOI：10.1248/bpb.29.841
出版社：The Pharmaceutical Society of Japan
摘要：A blood microdialysis technique coupled with high-performance liquid chromatography was used to investigate the pharmacokinetics of unbound ketoprofen in rats after intravenous administration of a lipid-soluble ketoprofen derivate, ketoprofen isopropyl ester (KPI), loaded into lipid microspheres (LM) and ketoprofen solution. A microdialysis probe was inserted into the jugular vein of male Wistar rats. KPI-loaded LM or ketoprofen solution (24 mg/kg, i.v.) was then administrated via a femoral vein. Dialysate samples were analyzed using HPLC. The in vitro and in vivo recovery rate of the microdialysis probe was 30.42±0.74% ( n =3) and 40.27±2.74% ( n =3), respectively. The pharmacokinetic parameters for ketoprofen after intravenous administration of KPI-loaded LM and ketoprofen solution exhibited no statistically significant differences. The results of this pharmacokinetic study indicate that the microdialysis technique can be widely applicable to investigations of in vivo free-drug of microcarrier systems.
关键词：ketoprofen isopropyl ester;ketoprofen;lipid microsphere;microdialysis;pharmacokinetics;HPLC