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标题：Hepatoprotective Compounds of the Roots of Cudrania tricuspidata on Tacrine-Induced Cytotoxicity in Hep G2 Cells
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作者：Ren-Bo An ; Dong-Hwan Sohn ; Youn-Chul Kim 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2006
卷号：29
期号：4
页码：838-840
DOI：10.1248/bpb.29.838
出版社：The Pharmaceutical Society of Japan
摘要：The bioassay-guided fractionation of the MeOH extract of the root barks of Cudrania tricuspidata furnished three hepatoprotective compounds, gerontoxanthone A (2), cudraflavone B (4), gericudranin E (5), together with four prenylated xanthones, cudraxanthone B (3), isocudraxanthone K (6), cudraxanthone C (7), cudraxanthone H (8), and a prenylated flavanone, euchrestaflavanone C (1). Compounds 4 and 5 showed significant hepatoprotective effects with the EC₅₀ values of 37.39±0.4 and 39.87±0.7 μ M , respectively, and compound 2 showed moderate hepatoprotective effect with an EC₅₀ value of 125.9±1.5 μ M , against tacrine-induced cytotoxicity in Hep G2 cells. Silybin as positive control showed an EC₅₀ value of 84.76±0.5 μ M . Isocudraxanthone K (6) is a new compound.
关键词：Cudrania tricuspidata;hepatoprotective;tacrine;Hep G2 cell;xanthone;flavonoid