文章基本信息

标题：Anti-complementary Activity of Ursane-Type Triterpenoids from Weigela subsessilis
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作者：Phuong Thien Thuong ; Byung-Sun Min ; WenYi Jin 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2006
卷号：29
期号：4
页码：830-833
DOI：10.1248/bpb.29.830
出版社：The Pharmaceutical Society of Japan
摘要：A new ursane-type triterpenoid, weigelic acid (1), and seven known compounds, ursolic acid (2), ilekudinol A (3), corosolic acid (4), ilekudinol B (5), esculentic acid (6), pomolic acid (7), and asiatic acid (8) were isolated from the leaf and stem of Weigela subsessilis . The structure of the new triterpenoid was established as 1β,2α,3α,23-tetrahydroxyurs-12-en-28-oic acid on the basis of spectroscopic analyses. In addition, the isolated compounds were evaluated for their anti-complement activity against the classical pathway of the complement system. Of these, compounds 1—2 and 4—8 exhibited anti-complement activity with IC₅₀ values of 152, 90, 130, 51, 56, 4, and 163 μ M , respectively, whereas 3 was inactive. This shows that a carboxylic group of ursane-type triterpenoids seems to play an important role in inhibiting the hemolytic activity of human serum against erythrocytes.
关键词：Weigela subsessilis;Caprifoliaceae;ursane-type triterpenoid;weigelic acid;anti-complementary