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标题：The Effects of BR003 on Memory and Cell Proliferation in the Dentate Gyrus of Rat Hippocampus
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作者：Myung Sook Oh ; Chan Park ; Youngbuhm Huh 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2006
卷号：29
期号：4
页码：813-816
DOI：10.1248/bpb.29.813
出版社：The Pharmaceutical Society of Japan
摘要：BR003 is a multi-herbal formula that contains twelve medicinal herbs. We investigated the effects of oral administration of BR003 to Wistar rats on (a) learning and memory using a passive avoidance test and (b) cell proliferation in the dentate gyrus (DG) of the hippocampus using immunohistochemical analysis of 5-bromo-2-deoxyuridine (BrdU) expression. In the passive avoidance test, the retention time of the BR003-treated group was significantly longer than that of the control group (182.64±39.88 vs. 73.08±29.30 s, respectively; n =11; p <0.05). There were significantly more BrdU-immunoreactive cells in the DG in the BR003-treated group than in the control group (1281.07±151.16 vs. 818.01±132.98 cells per DG, respectively; n =11; p <0.05). These results suggest that the administration of BR003 not only improves learning and memory but also increases cell proliferation in the DG of the rat hippocampus.
关键词：BR003;memory;cell proliferation;passive avoidance test;5-bromo-2-deoxyuridine