文章基本信息

标题：Changes in Immune Responses to Mite Antigen Sensitized through Barrier-Disrupted Skin with CpG-Oligodeoxynucleotide in Mice
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作者：Joe Inoue ; Satoshi Yotsumoto ; Takatoshi Sakamoto 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2006
卷号：29
期号：2
页码：385-387
DOI：10.1248/bpb.29.385
出版社：The Pharmaceutical Society of Japan
摘要：CpG-oligodeoxynucleotide (CpG-ODN) plays a critical role in immunity via the augmentation of Th1 and suppression of Th2 responses. We examined here the effect of CpG-ODN on the immune response to mite antigen sensitized through barrier-disrupted skin of human atopic dermatitis (AD) model mouse. Although sensitization with mite antigen induced Th2-dominant immune response, co-administration of CpG-ODN elicited Th1-predominant immune response. In terms of antigen-specific antibody production, the level of IgG2a was increased by CpG-ODN, but not in IgE. These results suggested that administration of CpG-ODN via skin is a simple strategy for patients with diseases like AD, which is characterized by Th2-dominated inflammation.
关键词：CpG-oligodeoxynucleotide (CpG-ODN);Th1/Th2 balance;transdermal administration;mite antigen;atopic dermatitis;NC/Nga mouse