文章基本信息

标题：Inhibition of Dehydroascorbic Acid Transport across the Rat Blood–Retinal and –Brain Barriers in Experimental Diabetes
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作者：Akito Minamizono ; Masatoshi Tomi ; Ken-ichi Hosoya 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2006
卷号：29
期号：10
页码：2148-2150
DOI：10.1248/bpb.29.2148
出版社：The Pharmaceutical Society of Japan
摘要：Vitamin C is mainly transported across the blood–retinal and –brain barriers as dehydroascorbic acid (DHA) via a facilitative glucose transporter, GLUT1, and accumulates as ascorbic acid in the retina and brain. To investigate whether DHA transport to the retina and brain is changed by hyperglycemia, [¹⁴C]DHA transport across the blood–retinal and –brain barriers was examined using in vivo integration plot analysis in streptozotocin-induced diabetic rats with a 3-week duration of diabetes and in normal rats. Blood-to-retina and -brain transport of [¹⁴C]DHA was reduced by 65.5% and 84.1%, respectively, in diabetic rats compared with normal rats, whereas there was no major difference in the heart. Therefore, we propose that hyperglycemia reduces the supply of vitamin C to the retina and brain.
关键词：dehydroascorbic acid;GLUT1;diabetes;blood–retinal barrier;blood–brain barrier