文章基本信息

标题：Antiviral Sulfated Polysaccharide from Navicula directa, a Diatom Collected from Deep-Sea Water in Toyama Bay
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作者：Jung-Bum Lee ; Kyoko Hayashi ; Megumi Hirata 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2006
卷号：29
期号：10
页码：2135-2139
DOI：10.1248/bpb.29.2135
出版社：The Pharmaceutical Society of Japan
摘要：A sulfated polysaccharide named naviculan was isolated from a diatom, Navicula directa (W. S MITH ) R ALFS , collected in deep sea water from Toyama Bay. The polysaccharide consisted of fucose, xylose, galactose, mannose, rhamnose and sulfate with an apparent molecular weight of 220000. It showed antiviral activities against herpes simplex viruses type 1 and 2, and influenza A virus with selectivity indices (CC₅₀/IC₅₀) of 270, 510 and 32, respectively. Naviculan also showed an inhibitory effect on cell–cell fusion between CD4-expressing and human immunodeficiency virus (HIV) gp160-expressing cells that was used as a model system of infection with HIV.
关键词：antiviral activity;polysaccharide;diatom;Navicula directa;deep sea water