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标题：Reduction of Cisplatin-Induced Nephrotoxicity by Ginsenosides Isolated from Processed Ginseng in Cultured Renal Tubular Cells
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作者：Seung Hoon Baek ; Xiang Lan Piao ; Un Jo Lee 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2006
卷号：29
期号：10
页码：2051-2055
DOI：10.1248/bpb.29.2051
出版社：The Pharmaceutical Society of Japan
摘要：Ginsenosides, the unique constituents and secondary metabolites of the Panax species, have been known to be the pharmacologically active ingredients of ginseng. Recently, our research group has developed a new processed ginseng, called Sun ginseng (SG), which has an increased amount of the red ginseng unique ginsenosides (RGUG). In our previous studies, this new processed ginseng reduced cisplatin-induced nephrotoxicity more than white ginseng in both in vitro and in vivo systems. In this study, we isolated and characterized active principles through activity-guided fractionation. Ginsenosides Rh₄ and Rk₃ significantly reduced the cisplatin-induced nephrotoxicity in LLC-PK₁ cells in a dose-dependent manner. The mechanisms of function and structure–activity relationships with other ginsenosides remain for further investigation.
关键词：ginsenoside;cisplatin-induced nephrotoxicity;LLC-PK1;processed ginseng