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标题：Effects of Solvents on Skin Permeation of Formoterol Fumarate
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作者：Ikuhiro Kakubari ; Noriko Nakamura ; Toshiyuki Takayasu 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2006
卷号：29
期号：1
页码：146-149
DOI：10.1248/bpb.29.146
出版社：The Pharmaceutical Society of Japan
摘要：Effects of various chemicals applied as penetration enhancers on the permeation of formoterol fumarate (FF) across excised rat skin were investigated. Remarkable enhancement was noted with terpenes, fatty acid esters, and higher alcohols, whereas no significant influence was observed in the case of lower alcohols, pyrrolidones, and amines. At high concentration, a cineole/ N -methyl-2-pyrrolidone (NMP) mixed solvent system slightly enhanced the skin permeation of FF compared with cineole alone, and a l -menthol/NMP mixed solvent system caused significant further increase. Maximum skin permeation of FF was seen when the ratio of l -menthol/NMP was 60/40 w/w. From the present results, l -menthol/NMP and isopropyl myristate (IPM)/NMP mixed solvent systems can be considered effective for augmenting skin permeation of FF, with potential applications in transdermal delivery of the drug.
关键词：skin permeation;formoterol;solvent;l-menthol;N-methyl-2-pyrrolidone