文章基本信息

标题：Vasorelaxant Effects of Methyl Brevifolincarboxylate from the Leaves of Phyllanthus niruri
本地全文：下载
作者：Toru Iizuka ; Hiroyoshi Moriyama ; Masahiro Nagai 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2006
卷号：29
期号：1
页码：177-179
DOI：10.1248/bpb.29.177
出版社：The Pharmaceutical Society of Japan
摘要：Methyl brevifolincarboxylate (1) isolated from the leaves of Phyllanthus niruri L. showed a vasorelaxant effect on rat aortic rings. Compound 1 exhibited slow relaxation activity against norepinephrine (NE)-induced contractions of rat aorta with or without endothelium. The compound did not affect contractions induced by a high concentration (60 m M ) of K⁺ , whereas it inhibited NE-induced vasocontraction in the presence of nicardipine. These results suggest that the inhibition of NE-induced vasocontraction by compound 1 is in part attributable to a decrease in [Ca²⁺]_i through receptor-operated Ca²⁺ channels.
关键词：Phyllanthus niruri;methyl brevifolincarboxylate;vasorelaxant effect;aorta;Ca2+ channel