文章基本信息

标题：Anti-inflammatory Effect of Propolis through Inhibition of Nitric Oxide Production on Carrageenin-Induced Mouse Paw Edema
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作者：Koichi Tan-no ; Takeharu Nakajima ; Takehiro Shoji 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2006
卷号：29
期号：1
页码：96-99
DOI：10.1248/bpb.29.96
出版社：The Pharmaceutical Society of Japan
摘要：The anti-inflammatory effect of propolis was compared with that of diclofenac, a non-steroidal anti-inflammatory drug, and L - N ^G-nitro arginine methyl ester ( L -NAME), a nitric oxide synthase inhibitor, using carrageenin-induced mouse paw edema. When administered 10 min prior to carrageenin injection, propolis (1 : 1000, 1 : 100, p.o. ), diclofenac (12.5, 50 mg/kg, p.o. ) and L -NAME (10, 100 mg/kg, s.c.) showed a significant anti-inflammatory effect. The anti-inflammatory effects of propolis and L -NAME were significantly inhibited by L -arginine, a precursor of nitric oxide, but not by D -arginine. In contrast, the anti-inflammatory effect produced by diclofenac was not inhibited by either D -arginine or L -arginine. These results indicate that the anti-inflammatory effect of propolis on mouse paw edema acts via the inhibition of nitric oxide production, similar to that of L -NAME but not diclofenac.
关键词：propolis;carrageenin;paw edema; L -NG-nitro arginine methyl ester;diclofenac;mouse