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标题：Inhibition of Hydrogen Peroxide, Nitric Oxide and TNF-α Production in Peritoneal Macrophages by Ethyl Acetate Fraction from Alchornea glandulosa
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作者：Flávia Cristine Mascia Lopes ; Tamara Regina Calvo ; Wagner Vilegas 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2005
卷号：28
期号：9
页码：1726-1730
DOI：10.1248/bpb.28.1726
出版社：The Pharmaceutical Society of Japan
摘要：The effects of Alchornea glandulosa ethyl acetate fraction (AGF) on hydrogen peroxide (H₂O₂), nitric oxide (NO) and tumor necrosis factor-α (TNF-α) production in peritoneal macrophages activated with lipopolysaccharide (LPS) or phorbol myristate acetate (PMA) were investigated. Analysis by thin layer chromatography (TLC) of AGF showed several constituents, including flavonoids, which may have anti-inflammatory activity. Inhibitory effects of the fraction in H₂O₂ and NO production ranged from 8.59±7.84% to 70.56±4.16% and from 16.06±3.65% to 38.73±3.90%, respectively. The TNF-α production was only partially inhibited in the tested concentrations (12.21±6.23%—15.16±0.96%). According to these results, it is suggested that AGF has anti-inflammatory activity. This medicinal plant may have therapeutic potential in the control of inflammatory disorders.
关键词：Alchornea glandulosa;anti-inflammatory activity;flavonoid;hydrogen peroxide;nitric oxide;TNF-α