文章基本信息

标题：Phosphatidylserine-Specific Receptor Contributes to TGF-β Production in Macrophages through a MAP Kinase, ERK
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作者：Masaki Otsuka ; Kentaro Goto ; Seishi Tsuchiya 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2005
卷号：28
期号：9
页码：1707-1710
DOI：10.1248/bpb.28.1707
出版社：The Pharmaceutical Society of Japan
摘要：We explored the involvement of the phosphatidylserine (PS)-receptor in the production of TGF-β by macrophages treated with PS-liposomes. The binding of anti-PS-receptor antibody to macrophages was specifically inhibited by PS-liposomes. The antibody led to an increase in the production of TGF-β, and also activated ERK, a member of the MAP kinase. But no activations in p38 and JNK were observed. ERK inhibitor, U0126 completely prevented TGF-β production. On the addition of a TGF-β neutralizing antibody or U0126, the inhibitory effect of the anti-PS-receptor antibody on macrophage function, nitric oxide production, was restored. These findings suggested that TGF-β is one of factors produced by PS-liposomes, and the ERK signaling pathway via the PS-receptor is intimately involved in the production of TGF-β in macrophages.
关键词：macrophage;nitric oxide;phosphatidylserine (PS)-receptor;PS-liposome;TGF-β, MAP kinase