文章基本信息

标题：7-Hydroxy-3-(4-hydroxybenzyl)chroman and Broussonin B: Neurotrophic Compounds, Isolated from Anemarrhena asphodeloides BUNGE, Function as Proteasome Inhibitors
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作者：Sachiko Tsukamoto ; Takeshi Wakana ; Keiichirou Koimaru 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2005
卷号：28
期号：9
页码：1798-1800
DOI：10.1248/bpb.28.1798
出版社：The Pharmaceutical Society of Japan
摘要：The extract of Anemarrhenae Rhizoma (rhizomes of Anemarrhena asphodeloides B UNGE ) showed neurotrophic activity toward rat pheochromocytoma (PC-12) cells. Bioassay-guided purification afforded four compounds, 2,6,4′-trihydroxy-4-methoxybenzophenone (1), 7-hydroxy-3-(4-hydroxybenzyl)chroman (2), broussonin B (3), and cis -hinokiresinol (4). Compounds 1—3 induced neurite outgrowth in PC-12 cells at concentration of 50 μg/ml, while 4 was less active. In addition, compounds 2—4 showed moderate inhibitory activities against a chymotrypsin-like activity of the proteasome.
关键词：Anemarrhena asphodeloides;neurotrophic;proteasome inhibitory activity