文章基本信息

标题：Elucidation of Anti-allergic Activities of Curcumin-Related Compounds with a Special Reference to Their Anti-oxidative Activities
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作者：Makoto Suzuki ; Tomonori Nakamura ; Sachi Iyoki 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2005
卷号：28
期号：8
页码：1438-1443
DOI：10.1248/bpb.28.1438
出版社：The Pharmaceutical Society of Japan
摘要：The anti-allergic and anti-oxidative activities of curcumin-related compounds (glycosides, reductants and bis -demethoxy analogs) were investigated to elucidate the underlying active mechanisms and structural features of curcumin in exerting these activities. The anti-allergic activities were assessed by measurement of histamine release from rat basophilic leukemia cells, RBL-2H3. Curcumin and tetrahydrocurcumin (THC) caused a marked decrease in histamine release. Glycosides of curcumin, bis -demethoxycurcumin and THC also inhibited the release of histamine, though less potently than curcumin did. The anti-oxidative activities were assessed by measurement of cell-free or cellular radical scavenging. All compounds but diglycosides or bis -demethoxycurcumin analogs distinctly exerted anti-oxidative effects. The relationship between both of these activities revealed that all compounds with potent radical scavenging activities caused a definite decrease in histamine release, but some compounds with non-potent radical scavenging activities also inhibited the histamine release. These results suggest that the hydroxy groups of curcumin play a significant role in exerting both the anti-oxidative and anti-allergic activities, and that most of the compounds develop the anti-allergic activities through mechanisms related to anti-oxidative activities, but some through mechanisms unrelated to anti-oxidation activity.
关键词：curcumin;tetrahydrocurcumin;anti-allergic effect;anti-oxidative effect;curcumin-related compound