文章基本信息

标题：A Phenoxazine Compound, 2-Amino-4,4α-dihydro-4α-7-dimethyl-3H-phenoxazine-3-one Reverses the Phenylephrine or High-K+ Induced Contraction of Smooth Muscles in Rat Aorta and Guinea Pig Tenia Cecum
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作者：Saifuding Musha ; Masaru Watanabe ; Yukisato Ishida 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2005
卷号：28
期号：8
页码：1521-1523
DOI：10.1248/bpb.28.1521
出版社：The Pharmaceutical Society of Japan
摘要：2-Amino-4,4α-dihydro-4α-7-dimethyl-3 H -phenoxazine-3-one (Phx-1) reversed concentration dependently the contraction of both rat aorta and guinea pig tenia cecum induced by phenylephrine or high-K⁺. Since Phx-1 suppresses the responses of human mononuclear cells to phytohemagglutinin, (Akazawa et al. Tohoku J. Exp. Med. , 196, 185—192, 2002), Phx-1 may be useful for developing new vasorelaxing agents with immunosuppressive action.
关键词：smooth muscle;aorta;tenia cecum;phenoxazine