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标题：Major Role of Soybean Oil in Preventing Decrease in CYP4A1 mRNA Content Relative to PPARα mRNA Down-Regulation in Infant Rats
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作者：Masuhiro Nishimura ; Aiko Yamauchi ; Mari Yamaguchi 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2005
卷号：28
期号：8
页码：1517-1520
DOI：10.1248/bpb.28.1517
出版社：The Pharmaceutical Society of Japan
摘要：Changes in the levels of CYP4A1, PPARα, and RXRα mRNA expression in the liver following overdose of fat-free or fat-containing total parenteral nutrition (TPN) were studied in 3-week-old male Sprague–Dawley rats. The rats were divided into three groups: group 1, oral diet; group 2, fat-free TPN; and group 3, TPN with 20% of calories from soybean oil emulsion. Levels of CYP4A1, PPARα, and RXRα mRNA in the fat-free TPN group were significantly lower than those in the other groups. Levels of CYP4A1 and PPARα mRNA were strongly correlated ( r =0.849), and levels of CYP4A1 and RXRα mRNA were weakly correlated ( r =0.618). This is the first report of a strong correlation between the levels of CYP4A1 and PPARα mRNA following overdose of fat-free or fat-containing TPN in infant rats. Our results also indicate that it is important to include fat in TPN regimens in order to prevent CYP4A1 mRNA down-regulation, which may be related to changes in PPARα mRNA levels in the liver.
关键词：fat;CYP4A1;peroxisome proliferators-activated receptor-α;infant rat liver;total parenteral nutrition;soybean oil emulsion