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标题：In Vitro Antifungal Activity of ZJ-522, a New Triazole Restructured from Fluconazole and Butenafine, against Clinically Important Fungi in Comparison with Fluconazole and Butenafine
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作者：Ping-Hui Gao ; Yong-Bing Cao ; Zheng Xu 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2005
卷号：28
期号：8
页码：1414-1417
DOI：10.1248/bpb.28.1414
出版社：The Pharmaceutical Society of Japan
摘要：The antifungal activity of ZJ-522, a new triazole antifungal agent restructured from fluconazole and butenafine, was compared to that of fluconazole and butenafine against 43 strains of fungi representing 13 fungal species. MICs were determined by using the National Committee for Clinical Laboratory Standards (NCCLS)-recommended broth microdilution method for yeasts, which was modified for filamentous fungi. ZJ-522 was about 50-fold and 2 to 16-fold more potent than fluconazole against yeasts and filamentous fungi respectively, but it was less active than butenafine against filamentous fungi, although butenafine was inactive against most yeasts. Thus, the fashion of ZJ-522 antifungal activity more similar to that of fluconazole than that of butenafine indicates that ZJ-522 should be an inhibitor of lanosterol 14α-demethylase but not of squalene epoxidase, and should be a candidate for clinical development.
关键词：ZJ-522;fluconazole;butenafine;antifungal activity;MIC