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  • 标题:Pharmacokinetics of Guanfu Base I, an Active Metabolite of Guanfu Base A, in Rats
  • 本地全文:下载
  • 作者:Xiaotian Li ; Guangji Wang ; Sujun Wang
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:2005
  • 卷号:28
  • 期号:8
  • 页码:1363-1365
  • DOI:10.1248/bpb.28.1363
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:A liquid chromatographic-mass spectrometric (LC-MS) method was developed and validated for determination of guanfu base I (GFI), and the pharmacokinetics of GFI in Sprague-Dawley rats was examined. The method was linear in the 0.05—20 μg/ml concentration range ( r =0.9994). The recovery of guanfu base I was more than 80%. The intraday and interday precision, expressed as the relative standard deviation (RSD), was generally good (<15%). After i.v. dosing, plasma GFI concentration declined in a bi-phasic manner with a terminal elimination half-life of 2.49 h. The total plasma clearance values was 1.46 l/h/kg. After oral dosing, the plasma GFI concentration reached a maximum within 0.5 h. The absolute bioavailability of GFI was 71.31%.
  • 关键词:guanfu base I;pharmacokinetics;LC-MS
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