文章基本信息

标题：Antitubercular Activity and Inhibitory Effect on Epstein-Barr Virus Activation of Sterols and Polyisoprenepolyols from an Edible Mushroom, Hypsizigus marmoreus
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作者：Toshihiro Akihisa ; Scott Gary Franzblau ; Harukuni Tokuda 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2005
卷号：28
期号：6
页码：1117-1119
DOI：10.1248/bpb.28.1117
出版社：The Pharmaceutical Society of Japan
摘要：Seven sterols (1—7) and eight polyisoprenepolyols (8—15), isolated from the non-saponifiable lipid fraction of the dichloromethane extract of an edible mushroom, Hypsizigus marmoreus (Buna-shimeji), were tested for their antitubercular activity against Mycobacterium tuberculosis strain H₃₇Rv using the Microplate Alamar Blue Assay (MABA). Six sterols (2—7) and two polyisoprenepolyols (8, 12) showed a minimum inhibitory concentration (MIC) in the range of 1—51 μg/ml, while the others (1, 9—11, 13—15) were inactive (MIC>128 μg/ml). The seven sterols (1—7) and three polyisoprenepolyols (8, 10, 12) were further evaluated for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12- O -tetradecanoylphorbol-13-acetate (TPA) in Raji cells. Sterols 6 and 7 showed potent inhibitory effects while preserving the high viability of Raji cells.
关键词：Hypsizigus marmoreus;sterol;polyisoprenepolyol;antituberculosis;Epstein-Barr virus early antigen