文章基本信息

标题：Effect of Chunghyuldan in Chronic Oxazolone-Induced Mouse Dermatitis
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作者：Sung-Sook Wee ; Yong-Wook Shin ; Eun-Ah Bae 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2005
卷号：28
期号：6
页码：1079-1082
DOI：10.1248/bpb.28.1079
出版社：The Pharmaceutical Society of Japan
摘要：To evaluate the antipsoriatic effect of Chunghyuldan (CHD, Daio-Orengedokuto in Japanese), which exhibited anti-inflammatory and antiischemic actions, the inhibitory activity of CHD metabolized with and without human intestinal microflora was investigated in oxazolone-induced mouse ear dermatitis. The CHD and metabolized CHD (MCHD) at concentrations of 0.1% also potently suppressed mouse ear swelling by 52.7% and 63.2% at 16 d, respectively. The antipsoriatic effect between CHD and MCHD was not significantly different, although that of CHD weakly increased by the metabolism of human intestinal microflora. Both CHD and MCHD also potently reduced the mRNA levels of cyclooxygenase (COX)-2, interferon (IFN)-γ and IL-4 increased in oxazolone-applied mouse ears, but weakly inhibited that of IL-1β and TNF-α. Based on these findings, CHD may improve contact dermatitis or psoriasis by the regulation of COX-2 produced by macrophage cells and IFN-γ and IL-4 produced by Th cells.
关键词：Chunghyuldan;Daio-Orengedokuto;psoriasis;contact dermatitis;COX-2: IFN-γ