文章基本信息

标题：AIP1, a Water-Soluble Fraction from Artemisia iwayomogi, Suppresses Thymocyte Apoptosis in Vitro and Down-Regulates the Expression of Fas Gene
本地全文：下载
作者：Jung Suk Hwang ; Hee Jung Ji ; Kyung Ah Koo 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2005
卷号：28
期号：5
页码：921-924
DOI：10.1248/bpb.28.921
出版社：The Pharmaceutical Society of Japan
摘要：The AIP1 fraction, a small water-soluble fraction purified from Artemisia iwayomogi , was shown to increase antibody production and suppress transplanted tumor cell growth in mice. In order to understand its immuno-modulating activity, we have examined the effect of the AIP1 on mouse thymocytes in vitro . Treatment of mouse thymocytes in culture with the fraction resulted in the suppression of the cell death and the extension of the cell survival. A mouse gene array provided a profile of gene expression change showing the pattern of up- and down-regulated genes by the AIP1 treatment, suggesting that the Fas/FasL-dependent apoptosis pathway might be modulated by the fraction.
关键词：Artemisia;apoptosis;thymocyte;Fas