文章基本信息

标题：Inhibition of Tyrosinase Activity by N,N-Unsubstituted Selenourea Derivatives
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作者：Sang Keun Ha ; Mamoru Koketsu ; Kunho Lee 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2005
卷号：28
期号：5
页码：838-840
DOI：10.1248/bpb.28.838
出版社：The Pharmaceutical Society of Japan
摘要：This study investigated inhibitory effects of N , N -unsubstituted selenourea derivatives on tyrosinase activity. Three types of N , N -unsubstituted selenoureas derivatives exhibited inhibitory effect on dopa (3,4-dihydroxyphenylalanine) oxidase activity of mushroom tyrosinase. Compound D at a concentration of 200 μ M exhibited 55.5% of inhibition on dopa oxidase activity of mushroom tyrosinase. This inhibitory effect was higher than that of kojic acid (39.4%), a well known tyrosinase inhibitor. Moreover, the compound D identified as a noncompetitive inhibitor by Lineweaver–Burk plot analysis. In addition, compound D also inhibited the melanin production in melan-a cells.
关键词：N,N-unsubstituted selenourea;tyrosinase inhibitor