文章基本信息

标题：Suppression of Proliferation of Poliovirus and Porcine Parvovirus by Novel Phenoxazines, 2-Amino-4,4α-dihydro-4α-7-dimethyl-3H-phenoxazine-3-one and 3-Amino-1,4α-dihydro-4α-8-dimethyl-2H-phenoxazine-2-one
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作者：Akiko Iwata ; Teruhide Yamaguchi ; Kouei Sato 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2005
卷号：28
期号：5
页码：905-907
DOI：10.1248/bpb.28.905
出版社：The Pharmaceutical Society of Japan
摘要：The present study aimed at investigating the antiviral effects of 2-amino-4,4α-dihydro-4α-7-dimethyl-3 H -phenoxazine-3-one (Phx-1) and 3-amino-1,4α-dihydro-4α-8-dimethyl-2 H -phenoxazine-2-one (Phx-2) on 6 representative viruses: poliovirus, porcine parvovirus, simian virus 40 (SV-40), herpes simplex virus-1 (HSV-1), Sindbis virus, and vesicular stomatitis virus (VSV). Phx-1 and Phx-2 suppressed the proliferation of poliovirus in Vero cells and that of porcine parvovirus in ESK cells at concentrations between 0.25 μg/ml and 2 μg/ml, when the cells were treated with Phx-1 and Phx-2 for 1 h and then inoculated with these viruses. The proliferation of the other viruses, SV-40, HSV-1, Sindbis virus, and VSV, in the host cells was not influenced by Phx-1 or Phx-2 at concentrations less than 20 μg/ml. The results suggest that Phx-1 and Phx-2 may be useful to prevent the proliferation of poliovirus and porcine parvovirus infection and may contribute to developing new antiviral drugs in future.
关键词：phenoxazine;poliovirus;porcine parvovirus