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标题：Study of the Absorption of Myo-Inositol Hexakisphosphate (InsP6) through the Skin
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作者：Felix Grases ; Joan Perelló ; Bernat Isern 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2005
卷号：28
期号：4
页码：764-767
DOI：10.1248/bpb.28.764
出版社：The Pharmaceutical Society of Japan
摘要：Recently, some properties of myo -inositol hexakisphosphate (InsP₆) are related to its dermatological use as discolouring agent, on preventing calcinosis cutis or due to its important role on premature aging. Some studies also seem to demonstrate a capacity of InsP₆ to inhibit skin cancer. In this paper, a first study of the absorption of InsP₆ through the skin is developed. Due to the correlation between InsP₆ absorption and its urinary excretion, these last values were used to evaluate this process. It was found that using a moisturizing cream as vehicle, the InsP₆ sodium salt was absorbed at significantly higher amounts than the InsP₆ calcium–magnesium salt. Maximum InsP₆ urinary concentrations were observed approximately at 14 d of 2% InsP₆ topical cream application, and gave 66.35±5.49 mg/l urinary InsP₆ when the sodium salt was used and 16.02±2.61 mg/l urinary InsP₆ when the calcium–magnesium salt was applied. When the InsP₆ topical cream administration ceased, the InsP₆ urinary excretion fell dramatically approximately during a period of 10 d. From these results, it can be deduced that by topical administration InsP₆ can achieve important concentrations in tissues and biological fluids, this demonstrating that it is possible to propose the topic use as a new InsP₆ administration route.
关键词：InsP6 skin absorption;urinary excretion;cream application;dermatological use