文章基本信息

标题：Pharmacokinetic Behavior of Micafungin in Rats with Carbon Tetrachloride-Induced Acute Hepatic Failure
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作者：Hiroki Konishi ; Masatomo Sudo ; Masaki Sumi 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2005
卷号：28
期号：3
页码：556-559
DOI：10.1248/bpb.28.556
出版社：The Pharmaceutical Society of Japan
摘要：We examined the pharmacokinetic behavior of micafungin, a novel antifungal agent, in rats receiving carbon tetrachloride (CCl₄) at a single dose of 2.5 ml/kg. There was no significant change in the total clearance ( CL _tot) in CCl₄-treated rats, while the steady-state volume of distribution ( Vd _ss) was significantly increased by CCl₄ treatment. Alteration in the serum unbound fraction of micafungin after CCl₄ treatment was unlikely in light of the serum albumin, bilirubin, creatinine, and urea nitrogen. The increased Vd _ss was attributable to augmentation in the accessibility of micafungin to peripheral tissue without impairment of the intrinsic clearance, because slight enhancement of the tissue distribution of micafungin was confirmed following CCl₄ treatment.
关键词：micafungin pharmacokinetics;acute hepatic failure rat;carbon tetrachloride;tissue distribution;elimination clearance