文章基本信息

标题：Effect of Aminated Gelatin on the Nasal Absorption of Insulin in Rats
本地全文：下载
作者：Toshinobu Seki ; Hiroshi Kanbayashi ; Tomonobu Nagao 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2005
卷号：28
期号：3
页码：510-514
DOI：10.1248/bpb.28.510
出版社：The Pharmaceutical Society of Japan
摘要：Absorption enhancers, which increase the permeability of drugs through epithelial membranes without damaging them, are especially useful for intranasal administration of peptide drugs. In this study, aminated gelatins, candidate enhancers, having different numbers of amino groups were prepared from gelatin (H-gelatin, isoelectric point=9.0, MW 100 kDa) and a partial gelatin hydrolysate (L-gelatin, isoelectric point=8.0, MW 5 kDa), and the enhancing effects on the nasal absorption of insulin, used as a model peptide drug, and 5(6)-carboxyfluorescein (CF), a paracellular marker, were examined in rats. The enhancing effect on insulin and CF depends on the MW and number of amino groups. A high correlation between the enhancing effects on insulin and CF was observed and this suggests that an increase in the paracellular permeability is the mechanism governing the nasal absorption-enhancement of aminated gelatins, at least as far as insulin and CF are concerned. The enhancing mechanism might be shared with other cationic polymers having absorption-enhancing effects.
关键词：nasal absorption;aminated gelatin;absorption enhancer;insulin