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标题：Antioxidant Effects of Aqueous Extracts from Dried Calyx of Hibiscus sabdariffa LINN. (Roselle) in Vitro Using Rat Low-Density Lipoprotein (LDL)
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作者：Vilasinee Hirunpanich ; Anocha Utaipat ; Noppawan Phumala Morales 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2005
卷号：28
期号：3
页码：481-484
DOI：10.1248/bpb.28.481
出版社：The Pharmaceutical Society of Japan
摘要：The present study quantitatively investigated the antioxidant effects of the aqueous extracts from dried calyx of Hibiscus sabdariffa L INN . (roselle) in vitro using rat low-density lipoprotein (LDL). Formations of the conjugated dienes and thiobarbituric acid reactive substances (TBARs) were monitored as markers of the early and later stages of the oxidation of LDL, respectively. Thus, we demonstrated that the dried calyx extracts of roselle exhibits strong antioxidant activity in Cu²⁺-mediated oxidation of LDL ( p <0.05) in vitro . The inhibitory effect of the extracts on LDL oxidation was dose-dependent at concentrations ranging from 0.1 to 5 mg/ml. Moreover, 5 mg/ml of roselle inhibited TBARs-formation with greater potency than 100 μ M of vitamin E. In conclusion, this study provides a quantitative insight into the potent antioxidant effect of roselle in vitro .
关键词：Hibiscus sabdariffa;roselle;low-density lipoprotein (LDL) oxidation;antioxidant