文章基本信息

标题：Radical Species in DNA Strand-Cleavage Caused by Dihydropyrazines
本地全文：下载
作者：Nobuhiro Kashige ; Toru Takeuchi ; Shigenobu Matsumoto 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2005
卷号：28
期号：3
页码：419-423
DOI：10.1248/bpb.28.419
出版社：The Pharmaceutical Society of Japan
摘要：Dihydropyrazines (DHPs), which generate hydroxyl and carbon-centered radicals, cleaved DNA single-strand. It is new knowledge that DHPs were recently determined to produce 8-hydroxydeoxyguanosine. The remarkable increase in the DNA strand-cleavage activity upon the addition of Cu²⁺ suggests that the primary reactive species is carbon-centered radicals rather than the hydroxyl radical generated the initiation reaction. This proposal was in fair agreement with of the observed carbon-centered radical signal intensity, but an effect was not observed with the increase in the hydroxyl radical signal intensity.
关键词：dihydropyrazine;DNA strand-cleavage;carbon-centered radical;hydroxyl radical