文章基本信息

标题：Inhibitory Effects of 4-n-Butylresorcinol on Tyrosinase Activity and Melanin Synthesis
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作者：Dong-Seok Kim ; So-Young Kim ; Seo-Hyoung Park 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2005
卷号：28
期号：12
页码：2216-2219
DOI：10.1248/bpb.28.2216
出版社：The Pharmaceutical Society of Japan
摘要：In this study, we investigated the effects of 4- n -butylresorcinol on melanogenesis in a spontaneously immortalized mouse melanocyte cell line, Mel-Ab. Our results show that 4- n -butylresorcinol significantly inhibits melanin synthesis in a concentration-dependent manner. In addition, it was also found to inhibit the activity of tyrosinase, the rate-limiting melanogenic enzyme. Several reports have indicated that the activation of extracellular signal-regulated kinase (ERK) or of Akt reduces melanin synthesis via microphthalmia-associated transcription factor (MITF) down-regulation. Accordingly, we examined the effects of 4- n -butylresorcinol on the ERK and Akt signaling pathways. 4- n -Butylresorcinol did not induce ERK, Akt activation, or MITF degradation, and had no effect on cAMP response element binding protein (CREB) phosphorylation, which stimulates MITF expression. In contrast, 4- n -butylresorcinol strongly reduced tyrosinase activity in a cell-free system. Moreover, 4- n -butylresorcinol showed an additive effect in combination with hinokitiol, which reduces MITF expression. These results show that the hypopigmentary effect of 4- n -butylresorcinol results from its direct inhibition of tyrosinase.
关键词：4-n-butylresorcinol;melanogenesis;tyrosinase;microphthalmia-associated transcription factor (MITF)