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标题：Regulation Effect of 2′,4′,7-Trihydroxyisoflavone on the Expression of Matrix Metalloproteinase-1, 2 in Ultraviolet-B Irradiated Primary Cultured Old Aged Human Skin Fibroblasts
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作者：Hyung In Moon ; Jong Hwan Kwak ; Ok Pyo Zee 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2005
卷号：28
期号：11
页码：2173-2175
DOI：10.1248/bpb.28.2173
出版社：The Pharmaceutical Society of Japan
摘要：Long term and repeated exposure of UV light on the skin often induces chronic skin diseases such as skin cancer as well as photoaging, and the mechanisms of these skin damages are closely associated with up-regulation of matrix metalloproteinase's (MMPs) activities. We investigated the effect of 2′,4′,7-trihydroxyisoflavone purified from the whole plants of Viola hondoensis W. B ECKER et H B OISSIEU (Violaceae) on the expression of MMPs in UV-B irradiated old aged human skin fibroblasts. 2′,4′,7-trihydroxyisoflavone markedly reduced UV-induced MMP-1 expression, but not MMP-2, at the both mRNA and protein levels in a dose-dependent manner. Our report is the first description for the ability of 2′,4′,7-trihydroxyisoflavone to regulate MMP-1 expression from ultraviolet-B irradiated primary cultured old aged human skin fibroblasts.
关键词：Viola hondoensis;2′,4′,7-trihydroxyisoflavone;matrix metalloproteinase (MMP)-1;MMP-2;aged human skin fibroblast