文章基本信息

标题：Antihyperlipidemic Effect of Crocin Isolated from the Fructus of Gardenia jasminoides and Its Metabolite Crocetin
本地全文：下载
作者：In-Ah Lee ; Jin Hee Lee ; Nam-In Baek 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2005
卷号：28
期号：11
页码：2106-2110
DOI：10.1248/bpb.28.2106
出版社：The Pharmaceutical Society of Japan
摘要：The pancreatic lipase inhibitors were isolated from the fructus of Gardenia jasminoides E LLIS , and their antihyperlipidemic activities were measured. Gardeniae fructus (GF) water extract inhibited pancreatic lipase activity. Crocetin and crocin were isolated from GF water extract as inhibitors of pancreatic lipase with an IC₅₀ value of 2.1 and 2.6 mg/ml (triolein as a substrate). Crocin and crocetin significantly inhibited the increase of serum TG level in corn oil feeding-induced triglyceridemic mice, as well as that of serum triglyceride and total and LDL cholesterol levels in Triton WR-1339-induced hyperlipidemic mice. These compounds also showed hypolipidemic activity in hyperlipidemic mice induced by high cholesterol, high fat or high carbohydrate diets for 5 weeks. The results suggest that the hypolipidemic activity of GF and its component crocin may be due to the inhibition of pancreatic lipase and crocin, and its metabolite, crocetin, can improve hyperlipidemia.
关键词：Gardeniae fructus;crocin;crocetin;pancreatic lipase;hypolipidemic activity