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标题：Decreased Tissue Accumulation of 6-Deoxy-6-[18F]fluoro-L-ascorbic Acid in Glutathione-Deficient Rats Induced by Administration of Diethyl Maleate
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作者：Fumihiko Yamamoto ; Tetsuo Kaneshiro ; Hiroharu Kato 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2005
卷号：28
期号：10
页码：1943-1947
DOI：10.1248/bpb.28.1943
出版社：The Pharmaceutical Society of Japan
摘要：The relationship between in vivo biodistribution of 6-deoxy-6-[¹⁸F]fluoro- L -ascorbic acid (¹⁸F-DFA) and the content of tissue glutathione (GSH) was investigated in Wistar male rats. Following intravenous administration of ¹⁸F-DFA, the accumulation of radioactivity in most tissues, including the adrenal glands, liver and brain, was significantly reduced together with a decrease in the content of GSH by preloading of diethyl maleate (DEM) which depletes cellular GSH. Similar decreased uptake was also observed in the distribution of L -[1-¹⁴C]ascorbic acid (¹⁴C-AA) after DEM treatment. The possible biological mechanisms, including competition with endogenous AA and ascorbate recycling, that modulate the uptake and accumulation into tissues of ¹⁸F-DFA and ¹⁴C-AA in GSH-deficient rats are discussed.
关键词：tissue distribution;6-deoxy-6-[18F]fluoro- L -ascorbic acid;glutathione;in vivo; L -[1-14C]ascorbic acid