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标题：CYP3A4 Inhibitors Isolated from Licorice
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作者：Sachiko Tsukamoto ; Maki Aburatani ; Tomohiro Yoshida 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2005
卷号：28
期号：10
页码：2000-2002
DOI：10.1248/bpb.28.2000
出版社：The Pharmaceutical Society of Japan
摘要：The extract of licorice ( Glycyrrhiza uralensis F ISHER , Leguminosae) showed CYP3A4 inhibitory activity with the IC₅₀ value of 0.022 mg/ml. Bioassay-guided purification afforded nine compounds, 3-( p -hydroxyphenyl)propionic acid (1), isoliquiritigenin (2), (3 R )-vestitol (3), licopyranocoumarin (4), 4-hydroxyguaiacol apioglucoside (5), liquiritin (6), liquiritigenin 7,4′-diglucoside (7), liquiritin apioside (8), and glucoliquiritin apioside (9). Among these compounds, 3, 7, and 5 showed potent CYP3A4 inhibitory activities with IC₅₀ values of 3.6, 17, and 20 μ M , respectively. Glycyrrhizin (10), a main constituent of licorice, however, was inactive for CYP3A4 inhibition.
关键词：Glycyrrhiza uralensis;licorice;CYP3A4 inhibitory activity