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标题：Anti-inflammatory and Antitumor-Promoting Effects of the Triterpene Acids from the Leaves of Eriobotrya japonica
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作者：Norihiro Banno ; Toshihiro Akihisa ; Harukuni Tokuda 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2005
卷号：28
期号：10
页码：1995-1999
DOI：10.1248/bpb.28.1995
出版社：The Pharmaceutical Society of Japan
摘要：Sixteen triterpene acids, viz. , five of the oleanane-type (1—5), nine of the ursane-type (6—14), and two of the lupane-type (15, 16), were isolated and identified from the ethyl acetate-soluble fraction of the methanol extract of the leaves of loquat, Eriobotrya japonica L INDL . (Rosaceae). Twelve of these compounds, 1—4, 6, 8—13, and 15, were evaluated for their inhibitory effects on 12- O -tetradecanoylphorbol-13-acetate (TPA)-induced inflammation (1 μg/ear) in mice. All the compounds tested showed a marked anti-inflammatory effect, with a 50% inhibitory dose (ID₅₀) of 0.03—0.43 mg per ear. In addition, an evaluation against the Epstein-Barr virus early antigen (EBV-EA) activation induced by TPA for all of the compounds, 12 and 13 showed potent inhibitory effects on EBV-EA induction. Furthermore, euscaphic acid (12) exhibited marked antitumor-promoting activity in an in vivo two-stage carcinogenesis test of mouse tumor by using 7,12-dimethylbenz[ a ]anthracene (DMBA) as an initiator and TPA as a promoter.
关键词：Eriobotrya japonica;triterpene acid;anti-inflammatory effect;antitumor-promoting effect;two-stage skin carcinogenesis