文章基本信息

标题：Hypotensive Activity, Toxicology and Histopathology of Opuntioside-I and Methanolic Extract of Opuntia dillenii
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作者：Rubeena Saleem ; Mohammad Ahmad ; Aisha Azmat 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2005
卷号：28
期号：10
页码：1844-1851
DOI：10.1248/bpb.28.1844
出版社：The Pharmaceutical Society of Japan
摘要：Methanolic extract of Opuntia dillenii cladodes and its pure compound α-pyrone glycoside, opuntioside-I showed potent hypotensive activity in normotensive rats. Both the extract and opuntioside-I showed comparable effect of 44—54% fall in Mean Arterial Blood Pressure (MABP) at the dose of 10 mg/kg. No mortality was observed in rats even at the doses of 1000 mg/kg/d and 900 mg/kg/d per oral of extract and opuntioside-I respectively. However, histopathology revealed adverse effects of high doses on liver and spleen of the experimental animals.
关键词：hypotensive activity;Opuntia dillenii cladodes;Opuntiae;α-pyrone glycoside;toxicology;histopathology