文章基本信息

标题：Effect of Sesamin in Acanthopanax senticosus HARMS on Behavioral Dysfunction in Rotenone-Induced Parkinsonian Rats
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作者：Takahiko Fujikawa ; Nariyasu Kanada ; Akihide Shimada 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2005
卷号：28
期号：1
页码：169-172
DOI：10.1248/bpb.28.169
出版社：The Pharmaceutical Society of Japan
摘要：The aim of this study was to determine whether sesamin, a component from Acanthopanax senticosus H ARMS (ASH) pharmacologically offers protection against Parkinson's disease (PD) and its related depressive behavior in rats administered rotenone. We also examined how sesamin affected the rotenone-induced loss of tyrosine hydroxylase (TH) or glial cell line-derived neurotrophic factor (GDNF)-positive neurons in the midbrain of rats. Rats were orally administered sesamin (3, 30 mg/kg) once a day for 2 weeks before an intraperitoneal injection of rotenone (2.5 mg/kg). The pole test and catalepsy test were used to evaluate the effects of sesamin administration on bradykinesia and depressive behaviors in the PD model of rats given rotenone for 5 weeks. Those effects were compared with the ASH administrated group (250 mg/kg). Treatment with sesamin for seven weeks resulted in prophylactic effects on rotenone-induced parkinsonian bradykinesia and catalepsy, and the effects were equivalent to ASH effects. Immunohistochemistical analysis using TH or GDNF antibody showed that sesamin provided cytoprotective effects against rotenone-induced loss of DA cells. The results suggest that it may be possible to use the ASH and sesamin for the prevention of nigral degenerative disorders, e.g. , PD with depression, caused by exposure to pesticide or environmental neurotoxins in general.
关键词：sesamin;Acanthopanax senticosus;rotenone;Parkinson's disease;bradykinesia;catalepsy