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标题：19α-Hydroxyursane-Type Triterpenoids: Antinociceptive Anti-inflammatory Principles of the Roots of Rosa rugosa
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作者：Hyun-Ju Jung ; Jung-Hwan Nam ; Jongwon Choi 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2005
卷号：28
期号：1
页码：101-104
DOI：10.1248/bpb.28.101
出版社：The Pharmaceutical Society of Japan
摘要：To search for antiinflammtory 19α-hydroxyursane-type triterpenoids, the MeOH extract of the roots of Rosa rugosa (Rosaceae) was fractionated. The active fraction of the EtOAc extract was hydrolyzed in alkaline solution to give a hydrolyzed fraction. Both extracts showed antiinflammatory/antinociceptive action in acetic acid-induced writhing and hot plate testing and in a carrageenan-induced paw edema model in mice and rats. Repeated chromatography of the EtOAc extract on both silica gel and octadecylsilane columns led to the isolation of kaji-ichigoside F₁ (1, euscaphic acid 28- O -glucoside) and rosamultin (2, tormentic acid 28- O -glucoside). The hydrolyzed fraction was also subjected to silica gel column and octadecylsilane column chromatography to produce euscaphic acid (3) and tormentic acid (4). The potencies were observed in the following order: 4>3>2>1. These results suggest that 19α-hydroxyursane-type triterpenoids are responsible for the antiinflammatory/antinociceptive action of R. rugosa roots.
关键词：Rosa rugosa;Rosacease;19α-hydroxytriterpenoid;euscaphic acid;antiinflammatory;antinociceptive