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标题：Antiinflammatory Activity of Astilbic Acid from Astilbe chinensis
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作者：Tae Chul Moon ; Chang Xiu Lin ; Joo Sang Lee 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2005
卷号：28
期号：1
页码：24-26
DOI：10.1248/bpb.28.24
出版社：The Pharmaceutical Society of Japan
摘要：This study examined the effect of astilbic acid (3β,6β-dihydroxyolean-12-en-27-oic acid), which is a herbal medicine isolated from Astilbe chinensis . Astilbic acid inhibited 5-lipoxygenase (5-LOX)-dependent leukotriene C₄ (LTC₄) generation in bone marrow-derived mast cells in a concentration-dependent manner with an IC₅₀ value of 2.1 μ M . In addition, astilbic acid was tested in a rat passive cutaneous anaphylaxis (PCA) reaction assay by administering 10 to 50 mg/kg i.p. Astilbic acid dose dependently inhibited the PCA reaction, which was activated by anti-dinitrophenyl (DNP) IgE. Furthermore, this compound inhibited mouse acetic acid-induced writhing (47—62% inhibition at 0.4—50 mg/kg) after being administered orally, while aspirin (200 mg/kg) showed 62% inhibition. These results suggest that astilbic acid may be beneficial in regulating various inflammatory processes.
关键词：Astilbe chinensis;astilbic acid;5-lipoxygenase;mouse bone marrow-derived mast cell;passive cutaneous anaphylaxis;analgesic activity