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标题：HIV-1 Inhibitory Compounds from Calophyllum brasiliense Leaves
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作者：Maira Huerta-Reyes ; Maria del Carmen Basualdo ; Fumiko Abe 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2004
卷号：27
期号：9
页码：1471-1475
DOI：10.1248/bpb.27.1471
出版社：The Pharmaceutical Society of Japan
摘要：The hexane, acetone and methanol extracts of Calophyllum brasiliense leaves were fractionated following a three bioassay guide: high HIV-1 RT inhibition, low cytotoxicity on MT2 cells and high inhibition of HIV-1 IIIb/LAV replication. This led to the isolation of three anti HIV-1 dipyranocoumarins: calanolides A and B and soulattrolide. In contrast, other isolated compounds such as apetalic acid, isoapetalic acid, a structural isomer of isoapetalic acid, friedelin, canophyllol and amentoflavone were devoid of HIV-1 RT inhibitory activity. Calanolide C was also obtained as a natural product and showed moderate inhibitory properties.
关键词：Calophyllum brasiliense;HIV-1 RT;calanolide