文章基本信息

标题：Inhibitory Effects of Extracts from Peels of Citrus natsudaidai Encapsulated in Hybrid Liposomes on the Growth of Tumor Cells in Vitro
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作者：Yutaka Kadota ; Chiho Taniguchi ; Shigeo Masuhara 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2004
卷号：27
期号：9
页码：1465-1467
DOI：10.1248/bpb.27.1465
出版社：The Pharmaceutical Society of Japan
摘要：Inhibitory effects of extracts from peels of Citrus natsudaidai ( natsumikan ) encapsulated in hybrid liposomes (HL) composed of L -α-dimyristoylphosphatidylcholine and polyoxyethylene (20) sorbitan monolaurate on the growth of tumor cells were examined. The extracts with lower polar solvents inhibited the growth of B-16 mouse melanoma and human lung carcinoma cells, although the extracts with higher polar solvents showed no antitumor activity. In particular, the inhibitory effects of extracts with lower polar solvents encapsulated in HL were enhanced as compared with those of free extracts. Fluorescence microscopic analysis indicated that the HL including petroleum ether extracts induced apoptosis in B-16 mouse melanoma cells. On the other hand, the viability of normal human fibroblast cells was even less affected by the extracts of natsumikan . These results suggest that hydrophobic antitumor agents should be present in peels of natsumikan .
关键词：Citrus natsudaidai;hybrid liposome;antitumor effect;apoptosis