文章基本信息

标题：Effects of Trifluoromethyl Ketones on the Motility of Proteus vulgaris
本地全文：下载
作者：Krisztina Wolfart ; Annamaria Molnar ; Masami Kawase 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2004
卷号：27
期号：9
页码：1462-1464
DOI：10.1248/bpb.27.1462
出版社：The Pharmaceutical Society of Japan
摘要：In the present study, we showed the inhibition of motility by trifluoromethyl ketone (TF) derivatives (1—8) in Proteus vulgaris ( P. vulgaris ) cultures. Among them, 1-(2-benzoxazoyl)-3,3,3-trifluoro-2-propanone (1) showed a much stronger inhibitory effect on the motility of P. vulgaris than other TF compounds at 10% MIC. Our results suggest the possibility of an inhibitory action of TF compounds on the proton motive forces by affecting the action of biological motor and proton efflux in the membranes, resulting in a reduction of the ratio of running and the increased number of tumbling and non-motile cells.
关键词：motility;Proteus vulgaris;trifluoromethyl ketone;proton pump