文章基本信息

标题：Role of Ca2+/Calmodulin Signaling Pathway on Morphological Development of Candida albicans
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作者：Tatsuki Sato ; Yukihiro Ueno ; Toshihiko Watanabe 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2004
卷号：27
期号：8
页码：1281-1284
DOI：10.1248/bpb.27.1281
出版社：The Pharmaceutical Society of Japan
摘要：A human fungal pathogen, Candida albicans , varies from the yeast form to the hyphal form due to various external signals. This morphogenetic transformation has been implicated in the development of pathogenicity. In this report, we show that calmodulin inhibitors (TFP and W-7) and an adenylatecyclase inhibitor (MDL-12-330A) suppressed the hyphae formation of C. albicans . Furthermore, the expression of hyphae-specific mRNAs located downstream from the RAS1-cAMP pathway was inhibited by these inhibitors. Suppression of hyphae formation by TFP or W-7 was not inhibited by the addition of cAMP, and these inhibitors did not affect the amount of cAMP in C. albicans . These results suggest that the Ca²⁺/calmodulin pathway contributes to hyphae formation and is related to the RAS1-cAMP pathway.
关键词：Candida albicans;hyphae formation;calmodulin;adenosine 3′,5′-cyclic monophosphate